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This version was published on May 1, 2008
American Journal of Alzheimer's Disease and Other Dementias®, Vol. 23, No. 2, 162-166 (2008)
DOI: 10.1177/1533317507312624

The Japanese MCI Screen for Early Detection of Alzheimer's Disease and Related Disorders

Ai Cho

Department of Neurology, Fukuoka University School of Medicine, Fukuoka, Japan

Mika Sugimura

Department of Neurology, Fukuoka University School of Medicine, Fukuoka, Japan

Seigo Nakano, MD, PhD

Department of Neurology, Fukuoka University School of Medicine, Fukuoka, Japan

Tatsuo Yamada, MD, PhD

Department of Neurology, Fukuoka University School of Medicine, Fukuoka, Japan, tyamada{at}fukuoka-u.ac.jp

Early detection of Alzheimer's disease and related disorders in Japan is increasingly important. The Mild Cognitive Impairment Screen (MCIS)—derived from the National Institute of Aging CERAD neuropsychologic battery—differentiates normal aging from MCI and mild dementia with 97.3% and 99% accuracy, respectively. The Japanese MCIS (JMCIS), Mini-Mental State Examination (MMSE), quantitative SPECT (qSP), and quantitative MRI (qMRI) were used to classify 63 outpatients at Fukuoka University Hospital who were either normal or had MCI based on Clinical Dementia Rating scores of 0 and 0.5, respectively. Performance statistics for the JMCIS, MMSE, qSP, and qMRI were, respectively: (1) accuracy = 0.964, 0.768, 0.722, 0.733; (2) sensitivity = 0.958, 0.792, 0.688, 0.700; (3) specificity = 1.000, 0.625, 1.000, 1.000; and (4) {kappa} validity = 0.813, 0.420, 0.296, 0.308. This initial study shows negligible differences between the English and Japanese MCIS, supporting its potential use for early detection in Japan.

Key Words: MCI Screen • MMSE • Neuroimaging • early detection • mild cognitive impairment • Alzheimer's disease and related disorders


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